Freedom to Explore
DNA Script’s groundbreaking Enzyme DNA Synthesis (EDS) platform can produce the single-stranded DNA sequence your experiments require, without compromising on length or complexity. See just how far you could go when the limitations are removed.
Meet our revolutionary Enzymatic DNA Synthesis platform
Access previously out-of-reach sequences
Avoid rejection and the need to redesign, our platform can accommodate your challenging projects including poly-A tails, telomeric sequences, ITRs and sequences with secondary structure.
Length no longer a limitation
Our groundbreaking EDS technology enables you to order oligos up to 500 nucleotides in length without the need to stitch together.
Benefit from natural DNA
Not only is Enzymatic DNA Synthesis more efficient, but it also has a much lower environmental impact than traditional DNA synthesis.
“Enzymatic DNA synthesis (EDS) has the potential to be faster and give higher-purity DNA with none of the drawbacks of the conventional phosphoramidite DNA synthesis method”
Science Advances, vol 9, Issue 27
How EDS works
1. Engineered Terminal Deoxynucleotidyl Transferase (TdT) adds reversibly-terminated nucleotides to the 3’-end of any single DNA strand with high fidelity and coupling efficiency.
2. Reversibly terminated nucleotide triphosphates (dNTPs) pause synthesis after a single base addition. These dNTPs are relatively small and rapidly and are efficiently restored using mild acidic conditions. They leave no scars, yielding completely natural, molecular biology-ready DNA.
3. A solid support allows for the control of synthesis scale and manipulating the growing oligo strands throughout the EDS process. The solid support has physical and chemical features optimized to enable the synthesis of ready-to-use long and complex DNA.
Capability
Long Oligos from 15 nt to 500 nt
• High accuracy of only 0.35% error rate
• 50 pmol delivered ready to use in ultrapure water
More Environmentally Friendly
• Large reduction in hazardous chemical use
• More sustainable
Complex DNA Designs
• High GC content, poly-A, ITR, UTR, promoters etc.
• No need to redesign to remove complexity
Reliability
• Typically ships within 10 business days
• Clear communication on delivery timelines
Redefine what's possible with our new ssDNA.
Our EDS-powered single-stranded DNA (ssDNA) is now ready to order. Be one of the first to see how far our oligo production capabilities can go by downloading the Excel template, adding your sequences and sending it to us using the form.
We'll reply to your request within 24 working hours.